6/13/2023 0 Comments Neuro hop forum9 In the others, morphological abnormalities such as hyperfolded myelin, characteristic of the so-called CMT-4b type, can be found in nerve biopsy specimens. 8 In truly or apparently recessively transmitted demyelinating polyneuropathy, the so-called Dejerine-Sottas disease, molecular genetics has identified a series of abnormalities in approximately two thirds of cases. 7 In patients with demyelinating CMT, molecular genetic testing has the greater chance of identifying the abnormality. In patients with well-defined hereditary Charcot-Marie-Tooth disease (CMT), it is necessary first to determine the axonal or demyelinating pattern of the disease, by electrophysiological testing, and the mode of transmission (dominant, recessive, or X-linked), to orient the molecular genetic testing. With hereditary neuropathies, it is now seldom necessary to perform a morphological study of a nerve biopsy specimen. Shared Decision Making and Communication. Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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